Semax is a synthetic heptapeptide (7 amino acids) engineered as an analog of residues 4–7 of adrenocorticotropic hormone (ACTH), with an added C-terminal Pro-Gly-Pro tripeptide extension that dramatically improves its protease resistance and CNS bioavailability compared to native ACTH fragments. It was originally developed and characterized in the Russian neuroscience literature and has an extensive preclinical research corpus in that language.

ProSource Labs supplies SEMAX in the following available vial sizes: 10mg. Each SEMAX vial contains pure lyophilized peptide — no fillers, no bulking agents. Product SKU references: SMAX-10MV.

• Peptide class: Synthetic 7-amino-acid ACTH(4-7) analog with Pro-Gly-Pro C-terminal extension
• Residue count: 7 amino acids
• Molecular weight: ~813 Da
• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
• Heptapeptide ACTH(4-7) analog with Pro-Gly-Pro C-terminal stabilization
• 7 amino acids; MW ~813 Da
• Extensive Russian preclinical neuroscience literature
• Water-soluble — dissolves readily in neutral aqueous diluents

Batches are characterized by ESI mass spectrometry to confirm molecular weight against the theoretical value, with amino-acid sequence confirmation on selected QA lots. Peptide content assay distinguishes net peptide mass from residual counter-ion salt.

Lyophilized SEMAX vials should be stored at -20°C (or colder) in a laboratory freezer, inside the sealed factory container. Minimize warm-up cycles — move only the specific vial needed for a given experiment out of frozen storage at a time.

All laboratory handling of SEMAX should follow the receiving institution's SOPs and applicable peer-reviewed protocols relevant to the researcher's specific experimental question. ProSource Labs does not publish end-user preparation or usage instructions.

Every batch of SEMAX released by ProSource Labs undergoes independent reverse-phase High Performance Liquid Chromatography (HPLC) — the industry-standard analytical method for this class of research compound. Target chromatographic purity is typically ≥ 99%.

Additional characterization may include ESI mass spectrometry for molecular weight confirmation, Karl Fischer titration for residual moisture, and appearance/solubility inspection. A batch-specific Certificate of Analysis (COA) is available on request through customer support after purchase.

Each production lot of SEMAX is quarantined pending analytical release, tested against documented purity, identity, and moisture acceptance criteria, and only released to sellable inventory after passing every QA checkpoint. Batches that fail any single criterion are quarantined and never reach customer-facing inventory.

If a vial of SEMAX you received from ProSource Labs ever fails your own institution's incoming QA testing, contact customer support at support@prosourcelabs.org — we retain samples of every batch for cross-verification.

Semax is used in preclinical rodent research on cognition, BDNF signaling, and neuroprotective pathways. Published preclinical literature (predominantly Russian, with a growing English-language body) has examined Semax effects on BDNF/TrkB signaling, hippocampal plasticity, cognitive-task performance, and ischemic-stroke rodent models. Its water-solubility and short peptide length make it a straightforward research compound to work with in cell-culture and in vivo rodent studies.

SEMAX vials ship in tamper-evident, moisture-resistant, cold-chain-friendly outer packaging from our Southern California distribution facility for fast US domestic delivery — typically 2-4 business days coast-to-coast, with expedited options available at checkout.

Every SEMAX shipment is discreet — the outer packaging carries no product-specific branding or direct reference to the compound name inside, protecting researcher privacy. Tracking numbers are emailed automatically. For institutional or high-volume orders, dedicated wholesale pricing is available through the wholesale portal.