Semaglutide is a synthetic 31-amino-acid analog of endogenous glucagon-like peptide-1 (GLP-1), engineered with two key modifications: an α-aminoisobutyric acid (Aib) substitution at position 8 (protecting against DPP-IV degradation) and an arginine substitution at position 34 that provides the attachment point for a C18 fatty-diacid side chain. That fatty-diacid side chain enables reversible albumin binding — the primary mechanism for Semaglutide's extended plasma half-life in preclinical models.

ProSource Labs supplies Semaglutide in the following available vial sizes: 10mg, 20mg. Each Semaglutide vial contains pure lyophilized peptide — no fillers, no bulking agents. Product SKU references: SEM-10MV, SEM-20MV.

• Peptide class: 31-amino-acid GLP-1 analog with fatty-diacid side chain
• Residue count: 31 amino acids
• Molecular weight: ~4,113 Da
• GLP-1 analog with Aib8 and Arg34 substitutions for DPP-IV resistance
• C18 fatty-diacid side chain enables reversible albumin binding
• 31 amino acids; MW ~4,113 Da
• Requires dilute acetic acid for solubilization (hydrophobic)

Batches are characterized by ESI mass spectrometry to confirm molecular weight against the theoretical value, with amino-acid sequence confirmation on selected QA lots. Peptide content assay distinguishes net peptide mass from residual counter-ion salt.

Lyophilized Semaglutide vials should be stored at -20°C (or colder) in a laboratory freezer, inside the sealed factory container. Minimize warm-up cycles — move only the specific vial needed for a given experiment out of frozen storage at a time.

All laboratory handling of Semaglutide should follow the receiving institution's SOPs and applicable peer-reviewed protocols relevant to the researcher's specific experimental question. ProSource Labs does not publish end-user preparation or usage instructions.

Every batch of Semaglutide released by ProSource Labs undergoes independent reverse-phase High Performance Liquid Chromatography (HPLC) — the industry-standard analytical method for this class of research compound. Target chromatographic purity is typically ≥ 99%.

Additional characterization may include ESI mass spectrometry for molecular weight confirmation, Karl Fischer titration for residual moisture, and appearance/solubility inspection. A batch-specific Certificate of Analysis (COA) is available on request through customer support after purchase.

Each production lot of Semaglutide is quarantined pending analytical release, tested against documented purity, identity, and moisture acceptance criteria, and only released to sellable inventory after passing every QA checkpoint. Batches that fail any single criterion are quarantined and never reach customer-facing inventory.

If a vial of Semaglutide you received from ProSource Labs ever fails your own institution's incoming QA testing, contact customer support at support@prosourcelabs.org — we retain samples of every batch for cross-verification.

Semaglutide is used in preclinical rodent and cell-culture research on GLP-1 receptor pharmacology and metabolic-pathway characterization. Published preclinical literature includes studies of glucose-dependent insulin secretion, gastric-emptying kinetics, hypothalamic food-intake circuits, and hepatic lipid metabolism. Semaglutide is the standard preclinical reference compound for single-receptor GLP-1 agonist studies — distinguishing it from dual-agonist (Tirzepatide, GLP-1 + GIP) and triple-agonist (Retatrutide, GLP-1 + GIP + Gcg) research peptides.

Semaglutide vials ship in tamper-evident, moisture-resistant, cold-chain-friendly outer packaging from our Southern California distribution facility for fast US domestic delivery — typically 2-4 business days coast-to-coast, with expedited options available at checkout.

Every Semaglutide shipment is discreet — the outer packaging carries no product-specific branding or direct reference to the compound name inside, protecting researcher privacy. Tracking numbers are emailed automatically. For institutional or high-volume orders, dedicated wholesale pricing is available through the wholesale portal.